Challenging the simplicity
Microfluidics and Organ on chip technologies
products
Culture patch was designed for 3D cell culture to reconstitute basement membrane in vitro. The culture patch was was obtained by self-assembling type IV collagen and laminin with a monolayer of crosslinked gelatin nanofibers and a patterned honeycomb microframe.
Advanced cell culture system has been developed for automated cell culture and stem cells differentiation. It is also flexible and robust for studying complex biological processes and building in vitro disease models by fluidic physiology condition mimicking.
Organ on chip is a high potential technology allowing simulating the mechanics and physiology of human organs in vitro. It turns out the powerful tools which can be used for acceleration of drug development: faster, lower cost and more accurate.
Integrated chips were manufactured by mass production. The upper part is a plastic plate with standard luer connectors and an elastomeric thin film for conformal contact with the lower part in which microfluidic circuits can be patterned. The lower part can be a sheet in plastic, elastomeric, glass, silicon or other materials.
Integration chips were designed for membrane or customized elements integration. An elastomeric thin film on the pre-patterned plastic plates could ensure good sealing without leakage when clamped. It can also be used to incorporate micro electro arrays/optical fibers for detection due to the flexibility of reversible assembling.
Flow controller was designed for experimentation in physics, chemistry, biology, biomedicine and different engineering fields. It is versatile and flexible, allowing easy and automatic control of complex fluidic (gas, liquid, electric) processes. It is a compact and open source platform for professional system development.
solutions & applications
Microfluidic solutions: from component to system
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Plug and Play: Integrated chips / Integration chips / Luer connection
- Simple and flexible: manual screwing clamp / multi chip clamp / pogo pin Electrode interface
- multi function system: multi channels processing / high precision control / open source program
- High resolution Imaging: microscope adaptable clamp / chambered coverslip
- real time monitoring: electrochemical detection / impedance spectroscopy
organ chip solutions: from cell culture patch to microphysiology
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Biomimicking: monolayer nanofiber / basement membrane reconstruction / organ chip
- Cell culture system : automatic medium exchange / long term IPS cells differenitation
- In-Vitro modeling: Epithelial-Endothelial co-culture/ lung model /BBB Model
- Microscopy: high resolution imaging / nitric oxide fluorescent probing
- Microphysiology: TEER monitoring / MEA electrophysiology measurement
bioproduction solutions: from validation to manufacturing
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Innovative micro devices : micro filter / Filter integration Chips / Microfluidic based bioreactor
- Micro emulsions: Homogeneous droplet / High throughput generation / New formula for cosmetics
- Platelet production: iPSC derived Megakaryocytes / Continuous high yield production
- Organoid production: IPSC Derived / on patch parallel production / Organoid for drug screening
technology
partner & customor
MesoBioTech is a spin-off of the microfluidics laboratory at the Ecole Normale Supérieure (ENS) of Paris with the participation of PSL foundation (Paris Science Letter Research University). The ENS laboratory itself is a part of the Institute of Pierre De Gennes for Microfluidics and the UMR 8640 of CNRS, ENS and Sorbonne University .
