Tissue patches are mostly derived from human induced pluripotent stem cells (hiPSCs). By changing the culture parameters, flat and hemisphere colonies are generated in each of the honeycomb compartment. Homogeneous cardiac and neuron tissues are produced, showing up-regulated gene expression of the specific proteins and regular beating or spontaneous firing.
When placed on a multi-electrode array, characteristic drug responses are observed. Tissue patches of co-cultured two cell layers are available, enabling different tissue models. More sophisticated tissue patches are also obtainable for three-dimensional tissue modeling.